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Synthesis
DOI: 10.1055/a-2705-6850
DOI: 10.1055/a-2705-6850
Short Review
π–π Interactions as Noncovalent Tools in Selective Catalysis
Authors
Supported by: National Research Foundation of Korea RS-2024-00342503
Funding Information This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. RS-2024-00342503).
Abstract
This short review describes recent advances in π–π stacking interaction-enabled catalysis for selective transformations. Owing to their charge-independent and spatially accessible nature, π–π interactions have been utilized to control chemo-, regio-, and stereoselectivity in a range of transformations. Selected examples are presented to illustrate how these noncovalent forces modulate transition-state geometry or stabilize key intermediates in C–C, C–O, and C–N bond formations, as well as in reductions and hydrogenation reactions.
Keywords
π–π Interactions - Noncovalent interactions - Selective catalysis bond formation - Selective reductionPublication History
Received: 18 July 2025
Accepted after revision: 02 September 2025
Accepted Manuscript online:
19 September 2025
Article published online:
22 October 2025
© 2025. Thieme. All rights reserved.
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